Custom Peptides
Cayman Chemical Dexrazoxane 10mg
An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals
Cayman Chemical TenapnorhydrochlorIde 10mg
An orally bioavailable NHE-3 inhibitor (IC50 = 10 nM for the recombinant rat protein); inhibits intestinal fluid absorption in mouse jejunum, but not distal colon, in a closed intestine loop assay at 10 µM; lowers both the sodium and phosphate urinary-to-dietary ratio in a dose-dependent manner in rats; reverses loperamide-induced decreases in stool pellet numbers and water content and prevents loperamide-induced constipation in mice at 5 mg/kg
Cayman Chemical JWH 018 2naphthylN 1 2dI 10mg
Differs from JWH 018 structurally by having a 1,2-dimethylpropyl chain, rather than a pentyl chain, extending from the indole group and the naphthyl moiety attached at its 2 position
Cayman Chemical BEChydrochlorIde 10mg
An inhibitor of arginase types I and II; inhibits rat liver arginase I (Kis = 0.4 and 0.6 µM from kinetic analyses); inhibits human arginase II (Kis = 310 and 30 nM at pH 7.5 and 9.5, respectively); enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro at 0.1-1 mM
Cayman Chemical SapacItabIn 10mg
A prodrug form of CNDAC; reduces tumor volume in an MV4-11 mouse xenograft model at 5 and 15 mg/kg alone or in combination with SAHA
Cayman Chemical SB-505124hydrochlorIde 10mg
An ALK5 and ALK4 inhibitor (IC50s = 47 and 129 nM, respectively); selective for ALK5 and ALK4 over a panel of 27 kinases at 10 µM; inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 µM; inhibits TGF-β-induced but not TNF-α-induced apoptosis in Fao cells at 1 µM; decreases IOP and subconjunctival immune cell infiltration in a rabbit model of trabeculectomy at 5 mg/eye
Cayman Chemical Gap 26trIfluoROCTAte salt 10mg
A connexin-mimetic peptide; inhibits phenylephrine-induced rhythmic contractile activity in isolated rabbit superior mesenteric arterial strips (IC50 = 28.4 µM); inhibits photoliberated Ins(1,4,5)-P3-induced ATP release in ECV304 cells at 0.25 mg/ml; decreases the infarct size in a rat model of myocardial infarction induced by left coronary artery occlusion at 0.5, 1, and 10 UG/kg
Cayman Chemical DM4hydrate 10mg
A derivative of maytansine; cytotoxic to SK-BR-3 cells (IC50 = 3.3 nM); selectivity cytotoxic to a variety of CD205-expressing human cancer cells (EC50s = 0.1-1.32 nM) over non-CD205-expressing cells (EC50s = 14.2-22.66 nM) and reduces tumor growth in various mouse xenograft and PDX cancer models when conjugated to a humanized CD205-targeting monoclonal antibody
Cayman Chemical CPTH6hydrobromIde 10mg
A thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP; blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines
Cayman Chemical S-2238hydrochlorIde 10mg
A chromogenic substrate for thrombin; enzymatic cleavage releases pNA which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity
Cayman Chemical LevomIlnacIprnhydrochLRId 10mg
A 5-HT and NE reuptake inhibitor (Kis = 11.2 and 92.2 nM, respectively; IC50s = 19 and 10.5 nM, respectively); selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM) and 23 receptors (Kis = ≥10,000 nM; increases extracellular 5-HT and NE in rat cortex (MEDs = 20 and 2.5 mg/kg); decreases immobility time in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively)
Cayman Chemical BRITE338733 10mg
A RecA inhibitor (IC50 = 4.7 µM for ATP hydrolysis in a cell-free assay)